Kisspeptin-10 is a decapeptide corresponding to the C-terminal ten residues of the kisspeptin family of peptides encoded by the KISS1 gene, and is treated in the literature as the shortest fragment that retains full agonist activity at its cognate receptor. AminoOptimization Group supplies it as a lyophilised research powder in a 10 mg presentation, tested to 99% purity by HPLC, with a Certificate of Analysis available for the lot supplied. This material is offered strictly for laboratory research use. It is not a drug, and it is not for human or veterinary use.
What is Kisspeptin-10?
Kisspeptin-10 (KP-10), also referenced in the literature as metastin (45–54), is a ten-residue, C-terminally amidated peptide with the sequence Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2. The terminal Arg-Phe-amide motif places it structurally within the RFamide peptide family, a group of C-terminally amidated signalling peptides sharing that same two-residue amide cap. Full-length kisspeptin is synthesised as a 145-amino-acid precursor and proteolytically processed into a series of shorter, biologically active fragments — kisspeptin-54, kisspeptin-14, kisspeptin-13, and kisspeptin-10 — all of which share this identical C-terminal decapeptide.
The kisspeptin family signals through KISS1R, also referred to in older nomenclature as GPR54, a Gq/11-coupled receptor that activates phospholipase C and downstream inositol trisphosphate and diacylglycerol signalling on binding. Because the receptor-binding determinants of kisspeptin are concentrated almost entirely in the shared C-terminal decapeptide, KP-10 is described in published pharmacology as functionally equivalent to the full-length peptide at the receptor, while differing substantially in pharmacokinetic behaviour.
That difference is what distinguishes KP-10 from longer kisspeptin fragments in study design. KP-10 is cleared rapidly in circulation, a property attributed to an internal Gly-Leu bond susceptible to cleavage by matrix metalloendopeptidases. Longer fragments such as kisspeptin-54 resist this degradation pathway and persist longer in solution. Researchers select between fragment lengths based on whether a study calls for a brief, sharply defined receptor stimulus or a sustained signalling exposure.
Specifications
- Compound: Kisspeptin-10 / Metastin (45–54)
- CAS number: 478507-53-8
- Molecular formula: C63H83N17O14
- Molecular weight: 1302.4 g/mol
- Purity: 99% by HPLC
- Presentation: Lyophilised powder, sealed vial
- Available sizes: 10 mg
- Physical form: White to off-white powder
- Classification: Research peptide — not for human or veterinary use
Research context
Published research on kisspeptin peptides is concentrated on the hypothalamic-pituitary-gonadal axis. Study designs examine how KISS1R agonism on GnRH neurons — concentrated in hypothalamic regions such as the arcuate nucleus and the anteroventral periventricular nucleus in rodent models — influences the frequency and amplitude of pulsatile GnRH release, and how that pattern is reflected in luteinising hormone secretion from the anterior pituitary in rodent, ovine, and primate model systems.
Because KP-10 is cleared quickly relative to longer kisspeptin fragments, it appears frequently in study designs probing acute receptor activation — single-bolus administration paradigms used to characterise LH pulse generation, contrasted against slower-clearance fragments or continuous-infusion protocols used to model receptor desensitisation. KISS1 signalling is also examined in reproductive axis maturation, including work on pubertal onset timing in animal models, and in metabolic-reproductive crosstalk research, since KISS1 neurons are reported to integrate peripheral energy-status signals upstream of the GnRH pulse generator.
None of this literature establishes safety or efficacy for use in humans. It is provided as research context only.
Reconstitution
Lyophilised peptide requires reconstitution with a suitable sterile diluent before use in solution. Bacteriostatic water is the diluent most commonly specified for multi-use laboratory preparations; sterile water is typical for single-use work.
Direct the diluent stream against the inner wall of the vial rather than onto the powder itself, and allow the material to dissolve without agitation. Peptides are susceptible to shear stress — do not shake the vial. Swirl gently if needed, and expect full dissolution within a few minutes at room temperature.
Working concentration is a function of how much diluent you add to a given vial mass. Our peptide reconstitution calculator computes the resulting concentration for any combination of vial size and diluent volume.
Storage and stability
Before reconstitution: store the sealed vial in a freezer at -20 °C, protected from light. Lyophilised peptide is comparatively stable in this state. Brief excursions to ambient temperature during shipping are normal and are not expected to compromise a properly lyophilised product.
After reconstitution: refrigerate at 2–8 °C and protect from light. Reconstituted peptide in solution is materially less stable than the dry powder. Avoid repeated freeze-thaw cycles, which are a well-documented cause of aggregation and loss of measurable potency — aliquot instead if repeated sampling is required.
Inspect solutions before use. Cloudiness, visible particulate, or discolouration indicate the material should not be relied upon for quantitative work.
Certificate of Analysis
Every lot is tested by high-performance liquid chromatography, and the purity figure shown above refers to analytical results for the specific lot supplied — not to a generic specification. A Certificate of Analysis is available on request, and we will provide lot-specific documentation before purchase if your protocol requires it.
Purity by HPLC describes the proportion of the target peptide relative to detectable related substances. It is a statement about the material as manufactured and tested. It is expressly not a representation that the material is suitable for any use in humans or animals.
Handling and safety
Handle in accordance with good laboratory practice. Use appropriate personal protective equipment, work in a suitable containment environment, and dispose of material and consumables according to your institution’s requirements and applicable local regulation. Anyone with access to this material should understand that it is not for human or veterinary use.
Frequently asked questions
What is the difference between Kisspeptin-10 and full-length kisspeptin (kisspeptin-54)?
Both share the same C-terminal decapeptide sequence responsible for KISS1R binding, and are described as pharmacologically similar at the receptor level. They differ in clearance: KP-10 is degraded and cleared much faster than the longer fragment, which is why researchers select between them based on whether a study calls for a brief or a sustained receptor signal.
Is Kisspeptin-10 approved in Canada?
No. This compound has not been evaluated or authorised by Health Canada, the FDA, or any comparable regulatory authority. It carries no DIN or NPN, its safety and efficacy for human use have not been assessed, and it is supplied for laboratory research only.
How much diluent should be used?
That depends on the working concentration your protocol requires. Use the reconstitution calculator to work out the resulting concentration for your vial size.
How long is reconstituted material usable?
Stability in solution is shorter than in lyophilised form and depends on diluent, temperature, and handling. Refrigerate at 2–8 °C, protect from light, avoid freeze-thaw cycling, and validate stability for your own storage conditions if your work depends on it.
Do you provide a Certificate of Analysis?
Yes — lot-specific, available on request, including before purchase.
Research use only
This product is supplied solely for laboratory and scientific research. It is not a drug, food, cosmetic, or medical device, and it must not be administered to humans or animals. Nothing on this page is medical advice or a therapeutic claim. Full terms are set out in our Research Use Only Disclaimer.
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