TIRZEPATIDE

Tirzepatide is a synthetic linear peptide of 39 amino acid residues, based on the native sequence of the incretin hormone glucose-dependent insulinotropic polypeptide (GIP) and modified to engage a second receptor target in addition to the GIP receptor. AminoOptimization Group supplies it as a lyophilised research powder in 10 mg, 15 mg, 30 mg and 60 mg presentations, tested to 99% purity by HPLC, with a Certificate of Analysis available for the lot supplied. This material is offered strictly for laboratory research use. It is not a drug, and it is not for human or veterinary use.

What is TIRZEPATIDE?

Tirzepatide is built as a single peptide chain engineered to bind two distinct G-protein-coupled receptors rather than one, a design the literature groups separately from earlier single-receptor incretin-mimetic peptides. Its backbone derives from GIP, with substitutions reported in published structure-activity work as conferring affinity at a second receptor alongside the native GIP receptor interaction.

A fatty diacid moiety is attached at an internal lysine residue via a short linker, a modification also seen in other long-acting peptide research compounds. Published characterisation associates this addition with reversible, non-covalent binding to serum albumin, which the literature reports as extending circulating half-life and reducing susceptibility to cleavage by dipeptidyl peptidase-4 relative to unmodified incretin peptide sequences.

Specifications

• Compound: Tirzepatide
• CAS number: 2023788-19-2
• Molecular formula: C₂₂₁H₃₄₈N₄₈O₆₈
• Molecular weight: 4813.53 g/mol
• Purity: 99% by HPLC
• Presentation: Lyophilised powder, sealed vial
• Available sizes: 10 mg, 15 mg, 30 mg, 60 mg
• Physical form: White to off-white powder
• Classification: Research peptide — not for human or veterinary use

Research context

Published research on dual-receptor incretin peptides examines how simultaneous agonism at two distinct receptors differs, at the level of receptor binding kinetics and downstream cyclic-AMP-mediated signal transduction, from agonism at either receptor alone. This work is carried out in cell-based expression systems and in rodent models, where receptor internalisation, signal duration, and tissue-level receptor distribution are the variables under study.

Comparative study designs pair dual-receptor peptides against selective single-receptor incretin-mimetic peptides to isolate the contribution of each receptor to observed cell signalling. None of this literature establishes safety or efficacy for use in humans. It is provided as research context only.

Reconstitution

Lyophilised peptide requires reconstitution with a suitable sterile diluent before use in solution. Bacteriostatic water is typically specified for multi-use laboratory preparations; sterile water is more common for single-use work.

Direct the diluent stream against the inner wall of the vial rather than onto the powder itself, and allow the material to dissolve without agitation. Peptides are susceptible to shear stress — do not shake the vial. Swirl gently if needed; full dissolution is typically observed within a few minutes at room temperature.

Working concentration depends on how much diluent is added to a given vial mass. Our peptide reconstitution calculator computes the resulting concentration for any combination of vial size and diluent volume.

Storage and stability

Before reconstitution: store the sealed vial in a freezer at -20 °C, protected from light. Lyophilised peptide is comparatively stable in this state. Brief excursions to ambient temperature during shipping are normal and are not expected to compromise a properly lyophilised product.

After reconstitution: refrigerate at 2–8 °C and protect from light. Peptide in solution is materially less stable than the dry powder. Avoid repeated freeze-thaw cycles, a well-documented cause of aggregation and loss of measurable material — aliquot instead if repeated sampling is required.

Inspect solutions before use. Cloudiness, visible particulate, or discolouration indicate the material should not be relied upon for quantitative work.

Certificate of Analysis

Every lot is tested by high-performance liquid chromatography, and the purity figure shown above refers to analytical results for the specific lot supplied — not to a generic specification. A Certificate of Analysis is available on request, and we will provide lot-specific documentation before purchase if your protocol requires it.

Purity by HPLC describes the proportion of the target peptide relative to detectable related substances. It is a statement about the material as manufactured and tested. It is expressly not a representation that the material is suitable for any use in humans or animals.

Handling and safety

Handle in accordance with good laboratory practice. Use appropriate personal protective equipment, work in a suitable containment environment, and dispose of material and consumables according to your institution’s requirements and applicable local regulation. Anyone with access to this material should understand that it is not for human or veterinary use.

Frequently asked questions

What distinguishes tirzepatide from single-receptor incretin peptides?

Tirzepatide is engineered to bind two distinct receptors within a single peptide chain, whereas earlier incretin-mimetic peptides act at one receptor only. Researchers use this structural difference to design comparative studies isolating each receptor’s contribution to cell signalling.

Is tirzepatide approved in Canada?

Tirzepatide is approved by Health Canada as the active ingredient in a prescription pharmaceutical product, available only through a licensed prescriber and dispensed under that product’s own Drug Identification Number. That authorisation applies to the approved pharmaceutical product specifically. This item is a separate, unformulated research compound: it has not itself been evaluated or authorised by Health Canada, carries no DIN or NPN of its own, is not sold as and must not be treated as equivalent to any approved pharmaceutical product, and is supplied strictly for laboratory research use.

How much diluent should be used?

That depends on the working concentration your protocol requires. Use the reconstitution calculator to work out the resulting concentration for your vial size.

How long is reconstituted material usable?

Stability in solution is shorter than in lyophilised form and depends on diluent, temperature, and handling. Refrigerate at 2–8 °C, protect from light, avoid freeze-thaw cycling, and validate stability for your own storage conditions if your work depends on it.

Do you provide a Certificate of Analysis?

Yes — lot-specific, available on request, including before purchase.

Research use only

This product is supplied solely for laboratory and scientific research. It is not a drug, food, cosmetic, or medical device, and it must not be administered to humans or animals. Nothing on this page is medical advice or a therapeutic claim. Full terms are set out in our Research Use Only Disclaimer.