CJC-1295 (No DAC), also referred to in the literature as Modified GRF (1-29), is a synthetic 29-amino-acid analogue of growth hormone-releasing hormone. AminoOptimization Group supplies it as a lyophilised research powder in 5 mg and 10 mg presentations, tested to 99% purity by HPLC, with a Certificate of Analysis available for the lot supplied. This material is offered strictly for laboratory research use. It is not a drug, and it is not for human or veterinary use.
What is CJC-1295 (No DAC)?
CJC-1295 without Drug Affinity Complex is a truncated GHRH analogue built on the first 29 amino acids of endogenous growth hormone-releasing hormone — the fragment identified in the literature as the minimum sequence retaining receptor activity. Four amino acid substitutions distinguish it from native GRF (1-29): these modifications are described in published work as reducing susceptibility to enzymatic degradation, particularly cleavage by dipeptidyl peptidase-4 at the N-terminus.
The “No DAC” designation is the practical distinction researchers care about. The DAC variant carries a maleimidopropionic acid group that binds covalently to serum albumin, extending its circulating half-life substantially. Without that complex, this analogue exhibits a much shorter profile — a property that makes it useful in study designs where a pulsatile rather than sustained signalling pattern is the variable under investigation.
Specifications
- Compound: CJC-1295 (No DAC) / Modified GRF (1-29)
- CAS number: 446036-97-1
- Molecular formula: C152H252N44O42
- Molecular weight: 3367.9 g/mol
- Purity: ≥99% by HPLC
- Presentation: Lyophilised powder, sealed vial
- Available sizes: 5 mg, 10 mg
- Physical form: White to off-white powder
- Classification: Research peptide — not for human or veterinary use
Research context
GHRH analogues are studied primarily for what they reveal about the somatotropic axis. Published research examines how GHRH receptor agonism at the anterior pituitary influences downstream signalling, and how the frequency and amplitude of that signal — rather than simply its presence — shapes observed outcomes in model systems.
Because the No DAC variant clears comparatively quickly, it appears in study designs investigating pulsatility: whether a short, sharp signal produces a different response profile than the prolonged elevation associated with albumin-bound analogues. It is also frequently examined alongside growth hormone secretagogue receptor ligands such as ipamorelin, since the two act through distinct receptor pathways and researchers use the combination to probe pathway interaction.
None of this literature establishes safety or efficacy for use in humans. It is provided as research context only.
Reconstitution
Lyophilised peptide requires reconstitution with a suitable sterile diluent before use in solution. Bacteriostatic water is the diluent most commonly specified for multi-use laboratory preparations; sterile water is typical for single-use work.
Direct the diluent stream against the inner wall of the vial rather than onto the powder itself, and allow the material to dissolve without agitation. Peptides are susceptible to shear stress — do not shake the vial. Swirl gently if needed, and expect full dissolution within a few minutes at room temperature.
Working concentration is a function of how much diluent you add to a given vial mass. Our peptide reconstitution calculator computes the resulting concentration for any combination of vial size and diluent volume.
Storage and stability
Before reconstitution: store the sealed vial in a freezer at -20 °C, protected from light. Lyophilised peptide is comparatively stable in this state. Brief excursions to ambient temperature during shipping are normal and are not expected to compromise a properly lyophilised product.
After reconstitution: refrigerate at 2–8 °C and protect from light. Reconstituted peptide in solution is materially less stable than the dry powder. Avoid repeated freeze-thaw cycles, which are a well-documented cause of aggregation and loss of measurable potency — aliquot instead if repeated sampling is required.
Inspect solutions before use. Cloudiness, visible particulate, or discolouration indicate the material should not be relied upon for quantitative work.
Certificate of Analysis
Every lot is tested by high-performance liquid chromatography, and the purity figure shown above refers to analytical results for the specific lot supplied — not to a generic specification. A Certificate of Analysis is available on request, and we will provide lot-specific documentation before purchase if your protocol requires it.
Purity by HPLC describes the proportion of the target peptide relative to detectable related substances. It is a statement about the material as manufactured and tested. It is expressly not a representation that the material is suitable for any use in humans or animals.
Handling and safety
Handle in accordance with good laboratory practice. Use appropriate personal protective equipment, work in a suitable containment environment, and dispose of material and consumables according to your institution’s requirements and applicable local regulation. Anyone with access to this material should understand that it is not for human or veterinary use.
Frequently asked questions
What is the difference between CJC-1295 with and without DAC?
The Drug Affinity Complex binds the peptide to serum albumin, which substantially extends its circulating half-life. Without it, clearance is much faster. Researchers select between them based on whether their study design calls for sustained or pulsatile signalling.
Is CJC-1295 approved in Canada?
No. This compound has not been evaluated or authorised by Health Canada, the FDA, or any comparable regulatory authority. It carries no DIN or NPN, its safety and efficacy for human use have not been assessed, and it is supplied for laboratory research only.
How much diluent should be used?
That depends on the working concentration your protocol requires. Use the reconstitution calculator to work out the resulting concentration for your vial size.
How long is reconstituted material usable?
Stability in solution is shorter than in lyophilised form and depends on diluent, temperature, and handling. Refrigerate at 2–8 °C, protect from light, avoid freeze-thaw cycling, and validate stability for your own storage conditions if your work depends on it.
Do you provide a Certificate of Analysis?
Yes — lot-specific, available on request, including before purchase.
Research use only
This product is supplied solely for laboratory and scientific research. It is not a drug, food, cosmetic, or medical device, and it must not be administered to humans or animals. Nothing on this page is medical advice or a therapeutic claim. Full terms are set out in our Research Use Only Disclaimer.
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