PT-141 is a synthetic cyclic heptapeptide within the melanocortin analogue class, more formally identified by its chemical name, bremelanotide. AminoOptimization Group supplies it as a lyophilised research powder in a 10 mg presentation, tested to 99% HPLC purity, with a Certificate of Analysis available for the lot supplied. This material is offered strictly for laboratory research use. It is not a drug, and it is not for human or veterinary use.
What is PT-141?
PT-141, catalogued under the CAS number given below as bremelanotide, is built on the sequence Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH. An acetylated norleucine residue sits at the N-terminus, a lactam bridge formed between the side chains of aspartate and lysine closes the seven-membered ring that defines this compound family, and the C-terminus ends in a free carboxylic acid rather than an amide.
That single structural detail is what separates PT-141 from its close relative, Melanotan II, which carries an identical sequence terminating instead in a C-terminal amide. The published chemistry treats PT-141 as the deamidated analogue of Melanotan II, and researchers use this distinction — along with the resulting difference in melanocortin receptor binding — to differentiate the two compounds in structure-activity work. Both belong to a wider family of synthetic analogues built on the pharmacophore of endogenous α-melanocyte-stimulating hormone (α-MSH).
Specifications
- Compound: PT-141 (Bremelanotide)
- CAS number: 1607799-13-2
- Molecular formula: C50H68N14O10
- Molecular weight: 1025.2 g/mol
- Purity: 99% HPLC
- Presentation: Lyophilised powder, sealed vial
- Available sizes: 10 mg
- Physical form: White to off-white powder
- Classification: Research peptide — not for human or veterinary use
Research context
Bremelanotide is studied in the literature as a nonselective agonist across the melanocortin receptor family, with reported affinity at the MC1R and MC4R subtypes. Published research in this area examines receptor binding kinetics and downstream cyclic AMP signal transduction, and situates these findings within structure-activity comparisons against other α-MSH-derived analogues, largely using cell-based and animal model systems.
None of this literature establishes safety or efficacy for use in humans. It is provided as research context only.
Reconstitution
Lyophilised peptide requires reconstitution with a suitable sterile diluent before use in solution. Bacteriostatic water is the diluent most commonly specified for multi-use laboratory preparations; sterile water is typical for single-use work.
Direct the diluent stream against the inner wall of the vial rather than onto the powder itself, and allow the material to dissolve without agitation. Peptides are susceptible to shear stress — do not shake the vial. Swirl gently if needed, and expect full dissolution within a few minutes at room temperature.
Working concentration is a function of how much diluent is added to a given vial mass. Our peptide reconstitution calculator computes the resulting concentration for any combination of vial size and diluent volume.
Storage and stability
Before reconstitution: store the sealed vial in a freezer at -20 °C, protected from light. Lyophilised peptide is comparatively stable in this state, and brief excursions to ambient temperature during shipping are normal and are not expected to compromise a properly lyophilised product.
After reconstitution: refrigerate at 2–8 °C and protect from light. Peptide in solution is materially less stable than the dry powder. Avoid repeated freeze-thaw cycles, a well-documented cause of aggregation and loss of measurable potency — aliquot instead if repeated sampling is required.
Inspect solutions before use. Cloudiness, visible particulate, or discolouration indicate the material should not be relied upon for quantitative work.
Certificate of Analysis
Every lot is tested by high-performance liquid chromatography, and the purity figure shown above refers to analytical results for the specific lot supplied, not to a generic specification. A Certificate of Analysis is available on request, and lot-specific documentation can be provided before purchase if your protocol requires it.
Purity by HPLC describes the proportion of the target peptide relative to detectable related substances. It is a statement about the material as manufactured and tested. It is expressly not a representation that the material is suitable for any use in humans or animals.
Handling and safety
Handle in accordance with good laboratory practice. Use appropriate personal protective equipment, work in a suitable containment environment, and dispose of material and consumables according to your institution’s requirements and applicable local regulation. Anyone with access to this material should understand that it is not for human or veterinary use.
Frequently asked questions
What is the difference between PT-141 and Melanotan II?
The two compounds share an identical amino acid sequence and cyclic lactam structure, differing only at the C-terminus: Melanotan II carries a terminal amide, while PT-141 (bremelanotide) terminates in a free carboxylic acid. Researchers use this distinction, and the resulting difference in receptor binding, to differentiate the two compounds in structure-activity studies.
Is PT-141 approved in Canada?
No. PT-141 has not been evaluated or authorised by Health Canada, the FDA, or any comparable regulatory authority. It carries no DIN (Drug Identification Number) or NPN (Natural Product Number), its safety and efficacy for human use have not been assessed under this listing, and it is supplied for laboratory research only.
How much diluent should be used to reconstitute PT-141?
That depends on the working concentration your protocol requires. Use the reconstitution calculator to work out the resulting concentration for your vial size.
How stable is PT-141 once reconstituted?
Stability in solution is shorter than in lyophilised form and depends on diluent, temperature, and handling. Refrigerate at 2–8 °C, protect from light, avoid freeze-thaw cycling, and validate stability for your own storage conditions if your work depends on it.
Do you provide a Certificate of Analysis for PT-141?
Yes — lot-specific, available on request, including before purchase.
Research use only
This product is supplied solely for laboratory and scientific research. It is not a drug, food, cosmetic, or medical device, and it must not be administered to humans or animals. Nothing on this page is medical advice or a therapeutic claim. Full terms are set out in our Research Use Only Disclaimer.
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