Thymalin is a low-molecular-weight polypeptide studied within the broader field of thymus-derived peptide bioregulators. AminoOptimization Group supplies it as a lyophilised research powder in a 10 mg presentation, tested to 99% purity by HPLC, with a Certificate of Analysis available for the lot supplied. This material is offered strictly for laboratory research use. It is not a drug, and it is not for human or veterinary use.
What is Thymalin?
The name Thymalin originates from a heterogeneous complex of low-molecular-weight polypeptide fractions isolated from calf thymus tissue, first described by Vladimir Khavinson and Vyacheslav Morozov at the Leningrad (now St Petersburg) Institute of Bioregulation and Gerontology in the 1970s. Their work proposed a class of tissue-specific “peptide bioregulators” — short peptides isolated from a given organ and studied for organ-restricted activity, in contrast to systemic hormones. Thymalin was the thymus-associated member of that research programme.
Material supplied under this listing corresponds to the specific CAS number, molecular formula and molecular weight given below: a single defined compound rather than the original multi-component extract described in early Soviet-era literature. Researchers comparing published data under the Thymalin name should note that distinction, since papers referring to the historical extract are not necessarily describing the same defined chemical entity. The molecular weight given here — 858.85 g/mol — is consistent with a compact synthetic oligopeptide, well below the multi-kilodalton range reported for some early thymus-extract fractions.
Within the wider set of thymic peptides studied in comparable research contexts — including thymosin alpha-1, a 28-residue peptide with an independently defined sequence, and thymogen, a dipeptide — Thymalin occupies its own structural niche, distinguished by the formula and molecular weight below. It falls under the general product classification “Peptide” rather than any of the tetrapeptide bioregulators (such as epitalon) that emerged from the same Leningrad research tradition.
Specifications
- Compound: Thymalin
- CAS number: 79621-14-0
- Molecular formula: C33H54N12O15
- Molecular weight: 858.85 g/mol
- Purity: 99% HPLC
- Presentation: Lyophilised powder, sealed vial
- Available sizes: 10 mg
- Physical form: White to off-white powder
- Classification: Research peptide — not for human or veterinary use
Research context
Published literature on thymus-derived peptide bioregulators, including material described under the Thymalin name, has focused chiefly on models of immune ageing and T-lymphocyte function. Study designs have examined how thymic peptide fractions influence thymocyte differentiation, peripheral T-cell subset distribution, and cytokine output in ageing rodent models, with particular attention to whether a short-duration peptide exposure is sufficient to shift these measures relative to untreated controls.
Because the peptide bioregulator framework in which Thymalin was originally described proposes tissue-restricted rather than systemic activity, it also appears in comparative study designs alongside bioregulator peptides isolated from other tissues — pineal, vascular, retinal — where researchers examine whether effects observed in one tissue’s model system transfer to another. Gene expression and chromatin-level endpoints have been reported in some of this literature as a proposed mechanism for tissue-restricted peptide activity, though the underlying mechanism remains an active subject of investigation rather than settled fact.
None of this literature establishes safety or efficacy for use in humans. It is provided as research context only.
Reconstitution
Lyophilised peptide requires reconstitution with a suitable sterile diluent before use in solution. Bacteriostatic water is the diluent most commonly specified for multi-use laboratory preparations; sterile water is typical for single-use work.
Direct the diluent stream against the inner wall of the vial rather than onto the powder itself, and allow the material to dissolve without agitation. Peptides are susceptible to shear stress — do not shake the vial. Swirl gently if needed, and expect full dissolution within a few minutes at room temperature.
Working concentration is a function of how much diluent is added to a given vial mass. Our peptide reconstitution calculator computes the resulting concentration for any combination of vial size and diluent volume.
Storage and stability
Before reconstitution: store the sealed vial in a freezer at -20 °C, protected from light. Lyophilised peptide is comparatively stable in this state, and brief excursions to ambient temperature during shipping are normal and are not expected to compromise a properly lyophilised product.
After reconstitution: refrigerate at 2–8 °C and protect from light. Peptide in solution is materially less stable than the dry powder. Avoid repeated freeze-thaw cycles, a well-documented cause of aggregation and loss of measurable potency — aliquot instead if repeated sampling is required.
Inspect solutions before use. Cloudiness, visible particulate, or discolouration indicate the material should not be relied upon for quantitative work.
Certificate of Analysis
Every lot is tested by high-performance liquid chromatography, and the purity figure shown above refers to analytical results for the specific lot supplied, not to a generic specification. A Certificate of Analysis is available on request, and we will provide lot-specific documentation before purchase if your protocol requires it.
Purity by HPLC describes the proportion of the target peptide relative to detectable related substances. It is a statement about the material as manufactured and tested. It is expressly not a representation that the material is suitable for any use in humans or animals.
Handling and safety
Handle in accordance with good laboratory practice. Use appropriate personal protective equipment, work in a suitable containment environment, and dispose of material and consumables according to your institution’s requirements and applicable local regulation. Anyone with access to this material should understand that it is not for human or veterinary use.
Frequently asked questions
Is Thymalin the same as the original Russian thymus-extract product sold under that name?
Not necessarily. Early literature describes Thymalin as a heterogeneous complex of polypeptide fractions extracted from calf thymus. The material supplied here corresponds to the single defined CAS number and molecular formula listed above, which is not the same thing as a multi-component tissue extract.
Is Thymalin approved in Canada?
No. This compound has not been evaluated or authorised by Health Canada, the FDA, or any comparable regulatory authority. It carries no DIN or NPN, its safety and efficacy for human use have not been assessed, and it is supplied for laboratory research only.
How does Thymalin differ from other thymic research peptides such as thymosin alpha-1?
Thymosin alpha-1 is a 28-residue peptide with an independently defined sequence and its own CAS number. Thymalin has a distinct, much smaller molecular formula and weight. Researchers should treat published data on one as specific to that compound and not transferable to the other.
How much diluent should be used?
That depends on the working concentration your protocol requires. Use the reconstitution calculator to work out the resulting concentration for your vial size.
Do you provide a Certificate of Analysis?
Yes — lot-specific, available on request, including before purchase.
Research use only
This product is supplied solely for laboratory and scientific research. It is not a drug, food, cosmetic, or medical device, and it must not be administered to humans or animals. Nothing on this page is medical advice or a therapeutic claim. Full terms are set out in our Research Use Only Disclaimer.
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